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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

BARRIGA C., Francisco et al. Trasplante de médula ósea en pacientes pediátricos. Rev. chil. pediatr. [online]. 1999, vol.70, n.3, pp.194-200. ISSN 0370-4106.  http://dx.doi.org/10.4067/S0370-41061999000300004.

Paediatric bone marrow transplantation (BMT) Objective: BMT is the only possible form of treatment in some infant haematological and oncological disorders. We describe a BMT programme implemented in our institute. Patients: 60 children, 37 boys and 23 girls, aged between 7 months and 17 years received BMT. The diagnosis was as follows: acute leukemia 24, aplastic anaemia 5, chronic myeloid leukemia/myelodysplasia 6, solid tumours 17, congenital disorders 17, histiocytosis 1. 14 patients had autologous BMT, 46 had allogenic transplants, whose donors were HLA matched siblings 34, HLA mis-matched family 6, matched unrelated donor (MUD) with cord stem cells 6. 31 patients were classified as standard risk and 29 high risk (refractory leukemia or solid tumour, multiply transfused, or HLA mis-matched or MUD transplants. Results: actuarial survival free of events (DFS) (3 years) total 36%, standard risk 61% and high risk 10% (p < 0.01). Conclusions: BMT is an effective treatment in paediatric patients without an alternative treatment. Results in advanced stage disease are disappointing, supporting the necessity of early and appropriate transplantation

Palabras clave : bone marrow transplantation; oncological disorders; cancer; leukemia.

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