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Revista chilena de pediatría

versión impresa ISSN 0370-4106


QUIAN, Jorge et al. Zidovudine chemoprophylaxis in the VIH(+) pregnant mother and her son. Rev. chil. pediatr. [online]. 2001, vol.72, n.1, pp.64-69. ISSN 0370-4106.

ACTG 076 protocol results about Zidovudine (AZT) quimioprofilaxis (QP) in order to reduce VIH vertical trasmission, were published in 1994, pregnant women who received AZT, gad a 8.4% transmission, compared with 24% of the ones who received placebo. Objetive: Evaluate AZT QP results. Methods: 304 mother-child couple histories, from Pereira Rossell Hospital, were retrospectively analized since june, 1990 to december, 1998. Complete QP was defined when HIV (+) pregnant women received oral AZT during one month or more before delivery, i/v AZT while delivery labor and when the newborno received during the first six weeks. Incomplete QP was defined when one or two parts of the complete treatment has failed. Children were clasified as: seroreverted (S), infected (I), perinatal exposes (E) following C.D.C. criteria. Results: Until december, 1994, 116 mother-child couple were studied and vertical transmission were found in 28.4%. In 1995, in 39 couples transmission was 29.03%. No couple received complete QP and 5 (15.6%) received incomplete QP. In 1996, in 60 couples, transmission was 31.6%, 7 of then (11.66%) received complete QP, and 22 (36 %) received incomplete QP. In 117, in 50 couples, transmission was 12%, 26 of then (52.9%) received complete QP, and 16 (31.3%) incomplete QP. In 1998 in 47 couples, transmission was 8.5%, 31 of then (65%) received complete QP, a 14 (29.78%) incomplete QP. Since january, 1995, 64 couples received complete QP, transmission was 6.25%, 57 couples received incomplete QP and transmission was 8.7%. In couples without QP, transmission was 43.2%. Conclusions: Since 1995, the number of couples that received AZT QP had a progresive increase, with a favourable impact in non infected newborns. VIH vertical transmission prevention obtained important results in Uruguay. To disminish infected children, and an adecquated cost-benefit relationship must be the objective for 100% mother-child couples.

Palabras clave : zidovudine; profilaxis; HIV; pregnancy.

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