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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

RS CUNHA, María de Lourdes; AM LOPES, Carlos; MSS RUGOLO, Lígia  y  VAS CHALITA, Liciana. Clinical significance of coagulase-negative staphylococci isolated of neonates. Rev. chil. pediatr. [online]. 2004, vol.75, n.3, pp.283-284. ISSN 0370-4106.  http://dx.doi.org/10.4067/S0370-41062004000300014.

Objective: To evaluate the clinical significance of coagulase-negative staphylococci (CNS) isolated from newborns’ infections at Unidade Neonatal do Hospital das Clínicas da Faculdade de Medicina de Botucatu. Method: The CNS strains isolated were identified and classified as clinically significant and contaminant, based on a series of clinical and laboratorial data obtained of the chart of the patients who stayed in the Neonatal Unit. The following data were analysed: risk factors for infections, clinical evolution, abnormal blood cell counts and/or C-reative protein e antibiotic therapy. Results: Of the 117 strains of CNS isolated, 60 (51,3%) were classified as significant and 57 (48,7%) as contaminant. Of the 54 infants infected by CNS, 43 (79,6%) were very low birth weight (< 1.500 g). Most of the infants infected by CNS were submitted to two or more procedures (77,8%), including catheter (88,9%), parenteral nutrition (64,8%) and mechanical ventilation (61,1%). Staphylococcus epidermidis was the most frequently isolated species (77,8%) and more associated with infection (86,7%) than with contamination (68,4%). Other species of CNS, including two strains of S. haemolyticus, three strains of S. lugdunensis, one strain of S. simulans, one strain of S. warneri and one strain of S. xylosus were also isolated from infants with clinical evidence of pneumonia, necrotizing enterocolitis and sepsis. Conclusion: Most of newborns infected by CNS presented important risk factors for the installation of the infectious process, including birth weight < 1 500 g, not removal foreign body and previous use of antimicrobials. The identification of species of ECN constitutes an useful marker of infection, since the S. epidermidis was the specie more frequently associated to the infection

Palabras clave : neonates; infection; coagulase-negative staphylococci; risk factors.

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