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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

MUNOZ B, ELIANA; OSSA A, JUAN CRISTÓBAL; VILLARROEL C, MILENA  y  SANTOLAYA DP, MARÍA ELENA. Antibiotic treatment in children with High Risk Febrile Neutropenia. Rev. chil. pediatr. [online]. 2008, vol.79, n.4, pp.381-387. ISSN 0370-4106.  http://dx.doi.org/10.4067/S0370-41062008000400005.

Background: In children with cancer and high risk febrile neutropenia (HRFN), the initial empirical treatment used in our hospital for 5 years includes the association of Cloxacillin + Ceftazidime + Amikacin. There is no chilean literature that reviews the effectiveness of this therapy. Objective: Evalúate the clinical and microbiological effectiveness of this associated therapy in children with HRFN. Method: A prospective-descriptive study evaluating children with HRFN admitted at Hospital Luis Calvo Mackenna between January 2005-August 2006. Results: 100 HRFN episodes were evaluated. In 48% of cases, the antimicrobial treatment was considered effective, whereas in 52% of episodes the therapy required modifications (15% cases within the first 72 hours). The most frequent diagnoses were fever without clinical focus (51%) and sepsis (13%). 36% had microbiological identification and the most frequently isolated bacteria were Escherichia coli (9%) and Staphylococcus aureus (9%). Conclusions: A favorable answer with the initial empirical therapy was obtained for 48% of cases; meanwhile in the remaining episodes, 28% required antibiotics modifications without justification. This fact remarks the importance of following the established guidelines for antimicrobial treatment modification in these patients

Palabras clave : Cancer; febrile neutropenia; antibiotics; oncology.

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