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Revista chilena de pediatría

Print version ISSN 0370-4106


MONTOYA C, IRENE et al. Clindamycin inducible resistance in methicillin-resistant Staphylococcus aureus. Rev. chil. pediatr. [online]. 2009, vol.80, n.1, pp.48-53. ISSN 0370-4106.

The increase in methicillin-resistant Staphylococcus aureus (MRSA) infections has limited the use of efective available antibiotics. Clindamycin, an alternative against MRSA, might have inducible resistance that is not detected by common antibiograms. The disk diffusion method (D-test) detects the inducible resistance. Objetive: To establish the frecuency of inducible resistance in MRSA from blood and secretion samples obtained from hospitalyzed patients. Methods: Prospective and descriptive research, including MRSA positive blood and secretion samples from patients of Hospital Luis Calvo Mackenna, between July 2005-July 2006. A D-test was performed to the samples. Results: 220 MRSA samples were obtained and D-test was performed on 155 of them. 80% of the samples carne from tracheobronquial secretion and 90%> had used antibiotics. From all analyzed MRSA isolates, 32 (20.6%o) were Clindamycin susceptible and 14 (43.8%) had Clindamycin inducible resistance (D-test+). Conclusions: A high percentage of MRSA Clindamycin resistant was found. From MRSA Clindamycin susceptible, 43.8%> had Clindamycin inducible resistance (D test+). D-test was implemented in the Microbiology Laboratory at Hospital Luis Calvo Mackenna, allowing the identification of MRSA isolates suceptible to Clindamicyn treatment.

Keywords : Clindamycin; antibiotic resistance; antibiotics; Staphylococcus aureus; Clindamicina; resistencia; antibiótico; Staphylococcus aureus.

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