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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

CABRERA F, CLEMENCIA et al. Insulin, Cortisol, IGF, IGFBP-3 and Maternal Anthropometric Variables in Full Term Newborns. Rev. chil. pediatr. [online]. 2010, vol.81, n.1, pp.20-27. ISSN 0370-4106.  http://dx.doi.org/10.4067/S0370-41062010000100003.

Introduction: Fetal growth is a physiological phenomenon involving maternal, placentary and fetal factors. Objective: To analyze growth factors and maternal anthropometric variables in full-term newborns (NB) and compare them to their size. Patients and Methods: 138 newborns, 37-41 gestational weeks, sorted according to size in low, normal and large for gestational age. Umbilical cord blood was measured for: ELISA, insulin, cortisol, IGF, IGFBP-3. Results: A statistically significant difference was seen between maternal weight at the beginning and end of pregnancy, and BMI (body mass index) at the beginning of pregnancy with the size of the NB (p < 0.001). There was no significant difference between growth factors and NB size. Conclusion: Insulin, Cortisol, IGF1, IGFBP-3 do not show statistically significant differences with the size of a newborn, although the mean value of growth factors in normal and large NB for gestational age, were twice than mean values in low for gestational age newborns. There is a positive, statistically significant correlation between the size of the newborn, and the size of the mother, weight at the beginning and end of the pregnancy and the Body Mass index of the mother at the beginning of the pregnancy.

Palabras clave : Insulin; cortisol; IGF-1; IGFBP-3; maternal antropometric variables.

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