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Revista chilena de pediatría

Print version ISSN 0370-4106


ACUNA A, MIRTA; BENADOF F, DONA; RODRIGUEZ G, PILAR  and  HERRERA L, PATRICIO. Use of antibiotics and expression of extended spectrum betalactamases (ESBL) in bacteremic agents. Rev. chil. pediatr. [online]. 2011, vol.82, n.3, pp.198-203. ISSN 0370-4106.

Objective: To evaluate the association between Escherischia Coli (E. Coli) and Klebsiella spp bacteremia, both of which produce Extended Spectrum beta-lactamases (ESBL), and the use of third generation cephalos-porines (TGC) during 30 days prior to the development of the infection. Patients and Methods: Case study of all patients hospitalized between 2004 and 2007 at Hospital de Niños Roberto del Río, who presented E. coli y Klebsiella spp bacteremia. Results: 212 episodes of E. coli o Klebsiella spp bacteremias were found; 205 contained all necessary data, 47 of which were cases and 158 were controls. The use of TGC showed a statistically significant correlation with the finding of ESBL in those patients' bacteremias (OR 2,5; IC95% 1,26-5). In addition, an independent statistically significant association was found with hospital acquired infections (OR 8,2; IC95% 2,7-27,1), and the use of Central Venous Catheter (OR 38,9; IC95% 14,3-106,0) became close to statistical significance. Conclusions: This study shows a statistically significant association between ESBL bacteremias and use of TGC within 30 days prior to the infection, confirming other literature reports.

Keywords : Bacteremia; Escherischia Coli; Klebsiella spp; antibiotics; beta-lactamases; ESBL.

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