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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

ELSO T, MARÍA JOSÉ; BROCKMANN V, PABLO  y  ZENTENO A, DANIEL. Consequences of obstructive sleep apnea syndrome in children. Rev. chil. pediatr. [online]. 2013, vol.84, n.2, pp.128-137. ISSN 0370-4106.  http://dx.doi.org/10.4067/S0370-41062013000200002.

The syndrome of obstructive sleep apnea (OSA) has emerged over the last decades as an important risk factor for heart and metabolic disease, and also, for neurocognitive dysfunction. The four major components of this condition are intermittent hypoxia, hypercapnia, intrathoracic pressure changes and sleep fragmentation. Several pathophysiological mechanisms are likely to be involved, such as increased oxidative stress, systemic inflammation and endothelial and autonomic dysfunction. Surgical treatment for OSA has been shown to be effective at normalizing endothelial function, reducing levels of inflammatory markers, and to improve the apnea-hypopnea index and sleep fragmentation, but this effect is smaller in obese children. The high prevalence of childhood obesity has changed the phenotypic expression of the disease, aggravating the problem and creating the need for effective interventions for this high-risk population. The aim of this study is to describe in detail the consequences of OSA on pediatric populations.

Palabras clave : Obstructive sleep apnea; consequences; children.

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