SciELO - Scientific Electronic Library Online

vol.86 número2Análisis de test de aire espirado en niños con sospecha de intolerancia a la lactosa índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google


Revista chilena de pediatría

versión impresa ISSN 0370-4106


ERRANZ M, Benjamín; WILHELM B, Jan; RIQUELME V, Raquel  y  CRUCES R, Pablo. Genetic predisposition and Pediatric Acute Respiratory Distress Syndrome: New tools for genetic study. Rev. chil. pediatr. [online]. 2015, vol.86, n.2, pp.73-79. ISSN 0370-4106.

Acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure. Theoretically, any acute lung condition can lead to ARDS, but only a small percentage of individuals actually develop the disease. On this basis, genetic factors have been implicated in the risk of developing ARDS. Based on the pathophysiology of this disease, many candidate genes have been evaluated as potential modifiers in patient, as well as in animal models, of ARDS. Recent experimental data and clinical studies suggest that variations of genes involved in key processes of tissue, cellular and molecular lung damage may influence susceptibility and prognosis of ARDS. However, the pathogenesis of pediatric ARDS is complex, and therefore, it can be expected that many genes might contribute. Genetic variations such as single nucleotide polymorphisms and copy-number variations are likely associated with susceptibility to ARDS in children with primary lung injury. Genome-wide association (GWA) studies can objectively examine these variations, and help identify important new genes and pathogenetic pathways for future analysis. This approach might also have diagnostic and therapeutic implications, such as predicting patient risk or developing a personalized therapeutic approach to this serious syndrome.

Palabras clave : Acute Respiratory Distress Syndrome; Acute Lung Injury; Pediatrics; Genetics; Single Nucleotide Polymorphisms; Genome-Wide Association Study.

        · resumen en Español     · texto en Español     · Español ( pdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons