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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

LUCIARDI, M. C. et al. Proinflammatory state in obese children. Rev. chil. pediatr. [online]. 2018, vol.89, n.3, pp.346-351. ISSN 0370-4106.  http://dx.doi.org/10.4067/S0370-41062018005000501.

Introduction:

Obesity is a chronic disease that affects adults as well as children and is associated with insulin resistance, type 2 diabetes and cardiovascular disease. One of the reasons for the presence of low-grade inflammation in these patients could be that adipose tissue of the obese produces proin flammatory molecules that favor the development of atherosclerosis.

Objective:

To determine serum levels of soluble CD40 ligand (sCD40L), monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), Tumor Necrosis Factor alpha (TNF-Α) and high sensitivity CRP (hsCRP), in an obese chil dren population compared to a control group, also to analyze the correlation of these molecules with the anthropometric and metabolic variables.

Patients and Method:

A cross-sectional, observational study was carried out on 37 obese children, aged 8 to 12 years, and 20 children with normal weight. Serum levels of sCD40L, MCP-1, IL-6, TNF-Α and hsCRP were determined. Data were expressed as the median and interquartil range and Spearman coefficient was used to investigate correlations between variables.

Results:

Compared to the control group, obese children presented significantly higher values of sCD40L, MCP-1, IL-6, TNF-Α, and hsCRP than control group. Body mass index and waist circumference correlated positively with sCD40L and MCP-1.

Conclusion:

Elevated levels of the studied molecules studied suggest the presence of low-grade inflammation associated with obesity in this population.

Palabras clave : Obesity; subclinical inflam mation; TNF-Α; hsPCR.

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