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Parasitología al día

versão impressa ISSN 0716-0720


ARAGORT DE ROSSELL, RAIZA et al. BLOOD AND CULTURE TRYPOMASTIGOTES FORMS OF Trypanosomacruzi Y.: II PATHOLOGY OF CHAGAS' DISEASE IN BALB/C MICE. Parasitol. día [online]. 2000, vol.24, n.3-4, pp.79-87. ISSN 0716-0720.

The histopathology and humoral response of BALB/c mice survivors after the infection with blood and culture forms of Trypanosoma cruzi was evaluated. The animals studied included those that survived the acute form of infection denominated Susceptible and those in which the parasite presence was detected only after an immune-suppresive treatment with cyclophosphamide called Less Susceptible. The autopsy of the animals revealed in all of them different grades of dilation of the colon while the miocardium was apparently of normal size. The histopathological studies of the gastrointestinal tract revealed miositis, miolisis and destruction of the mioenteric plexus. These alterations increased in intensity along the tract being slight to moderate from the cardias to the small intestine and intense in colon and rectum. Parasites were detected in only three cases. Pancreas alterations conducted to the loss of the gland architecture and consisted of intense oedema and inter-spaced inflamatore infiltrated between acinous cell and necrosis of the Langerhans' Islets. The histologic changes at the myocardium were slight. Small inflamatory foci of mononuclear cells were observed in the great vessels of the atriums and right ventricle. Parasites were not seen. Hight titles of specific IgG were detected in all animals. This histopathological study did not reveal differences relate to the origin of the trypomastigotes form

Palavras-chave : Trypanosoma cruzi; Protozoan; Difference of infectivity.

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