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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

MELLA M, SERGIO et al. MICROBIOLOGICAL PROPERTIES, CLASSIFICATIONS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF CEPHALOSPORINS AND THE IMPORTANCE OF FOURTH GENERATION CEPHALOSPORINS. Rev. chil. infectol. [online]. 2001, vol.18, n.1, pp.7-19. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182001000100002.

The cephalosporins are one of the most important types of ß-lactam antibiotics. There are various classifications of these molecules, but the most frecuently used classifies them according to their structures, microbiological properties and historical development: first to fourth generation cephalosporins. Third generation cephalosporins have been extensively used, but the emergence of bacterial resistance, mainly as a consecuence of chromosomal and plasmidial production of ß-lactamases has limited the use of these antibiotics. Fourth generation cephalosporins are characterized by the presence of a cuaternary nitrogen in C3; mantaining the methoxyimino aminothiazolyl in C7. Fourth generation cephalosporins display a high capacity of intracellular penetration through the external membranes of Gram negative rods and a low affinity to enzymes that degrade third generation cephalosporins. Cefepime, a fourth generation cephalosporin, has shown more inhibitory activity against chilean strains of Klebsiella pneumoniae and Escherichia coli that produce extended-spectrum ß-lactamases, than cefotaxime and ceftazidime

Palabras clave : Cephalosporins; Cefepime; Extended-spectrum ß-lactamases.

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