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Revista chilena de infectología

versión impresa ISSN 0716-1018


ROJAS R., Lázara; SARIEGO R., Idalia; SARRIA P., Carlos  y  FRAGA N., Jorge. Behavior "in vitro" of isolations of Trichomonas vaginalis, using mice NMRI as experimental model. Rev. chil. infectol. [online]. 2004, vol.21, n.3, pp.179-185. ISSN 0716-1018.

The correlation between clinical severity of vaginal trichomoniasis in adolescents and Trichomonas vaginalis virulence in an experimental model was studied. For this purpose, four hundred mice were inoculated intraperitoneally with 40 Trichomonas vaginalis isolates obtained from vaginal exudates. These were obtained from adolescents clinically classified as asymptomatic or mild, moderate or severe symptomatic patients, attending the Infant-Juvenile Service of Pregnancy Interruption and Sexually-Transmitted Diseases from Gynecoobstetrics Hospitals of the City of Havana. The ideal parasite concentration to inoculate turned out to be 8 x 106. The liver was the most affected organ, with a significant difference (p < 0,01) from the rest of the organs. Through Kruskal-Wallis test it was possible to observe that there were significant differences (p < 0,0001) among the score obtained by each mice group, depending on the kind of isolation, according to the clinical classification of origin. This demonstrated a possible correlation between the degree of virulence of each isolate and the clinical characteristics of the disease-carrying patients

Palabras clave : Trichomonas vaginalis; Adolescents; Virulence.

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