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Revista chilena de infectología

versão impressa ISSN 0716-1018

Resumo

SALAZAR E, M. Paulina et al. Cytomegalovirus infection and disease in pediatric solid organ transplantation: Experience in a Chilean multiorganic transplantation center. Rev. chil. infectol. [online]. 2009, vol.26, n.4, pp.311-317. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182009000500002.

Cytomegalovirus (CMV) infection and disease in transplant (Tx) recipients may severely complícate the patients outcome. Aim: To determine the incidence, clinical characteristics and risk factors for CMV infection and disease in liver and kidney transplant recipients in a tertiary care children's hospital. Method: A clinical and laboratory evaluation was prospectively performed in 44 and 20 children receiving a renal and liver Tx respectively in the Hospital Luis Calvo Mackenna between 2004 and 2006. Results: At the time of the organ Tx 20.3% (13/64) children were seronegative for CMV. Thirty six per cent (23/64) patients were infected with CMV, of whom 32% (14/44) received kidney Tx and 9/20 (45%) received liver Tx. CMV disease occurred in 52% (12/23) of infected patients. CMV disease was characterized by fever (100%), anemia (50%), leucopenia (16.6%) and specific organ involvement (renal graft 60% liver graft 57.1%, lung 25%, intestine 16.6%). Variables significantly associated with infection were a CMV seronegative status (p = 0.035) and lower age 5.5 + 3.7 years oíd vs 8.3 + 4.4 years oíd (p = 0.01). Conclusions: Incidence of CMV infection was high in children receiving a solid organ transplant in our institution and near half of infected children developed CMV-associated disease.

Palavras-chave : Cytomegalovirus (CMV); infection; solid organ transplantation; pediatrics.

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