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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

IZQUIERDO, Giannina  y  PROGRAMA NACIONAL INFANTIL DE DROGAS ANTINEOPLASICAS (PINDA). Subcomité de Enfermedades Infecciosas et al. Seroprevalence of varicella-zoster virus in children with cancer in six hospitals in Santiago, Chile. Rev. chil. infectol. [online]. 2012, vol.29, n.6, pp.595-599. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182012000700002.

Infections with varicella-zoster virus (VVZ) in immunocompromised children imply a high mortality. There is no data about VVZ seroprevalence in children with cancer in our country. Aim: To determine the prevalence of VVZ antibodies in children with cancer who have undergone chemotherapy or have undergone a hematopoietic stem cell transplant. Methodology: collaborative, multicenter study. Serum samples were collected from 281 children with cancer and episodes of febrile neutropenia from 6 hospitals belonging to the public health network in the Metropolitan Region between June 2004 and August 2006. These samples were stored at -70 ° C, and 200 of them were randomly chosen and analyzed to determine VVZ IgG (ELISA). Results: 179 samples from 179 children, 65% male. Ninety eigth/179 (55%) were positive, 72/179 (40%) negative and 9/179 (5%) indeterminate. Stratified by age, seropositive percentage was: 1 to 4 years 32%, 5-9 years 42%, 10-14 years 78%, over 15 years 88%. Conclusion: Forty percent of children treated for cancer are seronegative to VVZ infection, a frequency that decreases with age. These results support the adoption of preventive measures to avoid infection in this population of children at risk of developing a serious and possibly fatal illness.

Palabras clave : Seroprevalence; varicella-zoster virus; immunocompromised.

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