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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

MAGAZ, María de las Mercedes et al. Clinical characteristics of adult patients with herpetic meningoencephalitis: a nested case control study. Rev. chil. infectol. [online]. 2015, vol.32, n.3, pp.266-271. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182015000400002.

Introduction: Herpes simplex virus (HSV) is the most common etiology of sporadic encephalitis and presents with an estimated mortality of 50-70%. Objective: To describe baseline characteristics of patients with herpetic encephalitis admitted to a tertiary teaching hospital and their difference with patients with non herpetic encephalitis. Materials and Methods: Nested case control study using a retrospective cohort of patients with suspected encephalitis admitted to the Hospital Italiano de Buenos Aires (2006-2013). Adult patients included had a lumbar puncture with a positive or negative polimerase reaction for HSV. A case of herpetic encephalitis was defined as a positive polimerase reaction in spinal fluid. For each case, 5 controls were randomly selected. Results: There were no baseline differences present between cases and controls. The only covariate associated with herpetic encephalitis was an abnormal brain magnetic resonance imaging (MRI) (OR: 5.37, IC 95% 1.42-20.38, p < 0.01). The most frecuent alterations in the MRI were extratemporal lesions or temporal ones with or without haemorrhage. Discussion: There are no apparent baseline clinical differences between patients with or without herpetic encephalitis. A positive finding in a brain MRI should be taken into account during clinical workup.

Palabras clave : Herpes simplex virus; meningoencephalitis; herpetic; encephalitis; prognosis.

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