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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

GUEVARA, Napoleón et al. Antimicrobial susceptibility patterns of Gram-negative bacteria isolated in urinary tract infections in Venezuela: Results of the SMART study 2009-2012. Rev. chil. infectol. [online]. 2015, vol.32, n.6, pp.639-648. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182015000700005.

Introduction: Antimicrobial resistance of pathogens causing urinary tract infection (UTI) is a growing problem, which complicates their effective treatment. Surveillance is needed to guide appropriate empiric therapy. Aim: to describe the susceptibility patterns of Gram-negative bacteria isolated of patients with UTI to twelve antibiotics as part of the Study for Monitoring Antimicrobial Resistance Trends in Venezuela. Materials and Methods: Between 2009-2012 a total of 472 Gram-negative bacteria were isolated from hospitalized patients with UTI. The isolates were sent to Central Laboratory (Central Laboratory of International Health Management Associates) to confirm their identification, and to make susceptibility testing as recommended by the Clinical and Laboratory Standards Institute. Enterobacteriacea comprised 96.6% of the total, where Escherichia coli (76.9%) and Klebsiellapneu-moniae (10.6%) were the most frequent. Extended-spectrum β-lactamases (ESBL) was detected in 21.6% of isolates. Top antimicrobial activity were ertapenem, imipenem, and amikacin (> 90.0%), slightly lower for amikacin (85.1%) in ESBL-producing strains. Resistance rates to fluoroquinolones and ampicillin/sulbactam were high (40 y 64%, respectively). Conclusions: These data suggest a necessary revision of the therapeutic regimens for the empirical treatment of UTI in Venezuela.

Palabras clave : SMART; urinary tract infections; extended-spectrum β-lactamase; ESBL; susceptibility.

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