SciELO - Scientific Electronic Library Online

vol.33 issue4The water supply of a pediatric hospital as a possible source of an outbreak of diarrhea due to Microsporidium spp. in immunocompromised patientsGastos hospitalarios por neumonía neumocóccica invasora en adultos en un hospital general en Chile author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Revista chilena de infectología

Print version ISSN 0716-1018


GUTIERREZ, Valentina et al. Parechovirus as etiologic agent of meningitis and/or sepsis like illness in infants. Rev. chil. infectol. [online]. 2016, vol.33, n.4, pp.380-388. ISSN 0716-1018.

Introduction: Human parechovirus (HPeV) belongs to the Picornaviridae family and has been described in viral meningoencephalitis ans sepsis like illness in infants. Until now, 16 genotypes have been recognized, the most common are HPeV 1, 2 and 3; type 3 is most severe. Aims: To estimate the frequency of HPeV etiology in viral meningoencephalitis and sepsis in infants and characterize clinical and molecular aspects of infection. Methods: Between October 2013 and March 2015 we collected CSF samples, plasma, nasopharyngeal swabs and/or stools of patients younger than two years with suspected sepsis and/or viral meningitis. Samples were obtained from laboratory storage sites and from hospitalized patients. HPeV was diagnosed by real-time polymerase chain reaction (PCR) assay against the 5'UTR region. Positive samples were genotyped by sequencing a 304pb segment in VP3/VP1 overlapping region obtained with a nested PCR. Results: Overall HPeV detection rate was 18,6% (11/59 patients), distributed in 8.7% (4/46) laboratory's samples and 53.8% (7/13) of samples from hospitalized patients; mean age was 49 days (18 days-6 months). Most common clinical signs (11/11 patients) were irritability, inappetance, and fever (magnitude 38-38.8°C). All six samples genotyped were HPeV 3. Conclusions: HPeV should be considered as a relatively significant etiologic agent of viral meningoencephalitis and sepsis in infants.

Keywords : Human Parechovirus; Sepsis like syndrome; infants; children.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License