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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

PEREZ-LAZO, Giancarlo; MAQUERA-AFARAY, Julio; MEJIA, Christian R.  y  CASTILLO, Raúl. Disseminated histoplasmosis and HIV infection: Case series in a Peruvian hospital. Rev. chil. infectol. [online]. 2017, vol.34, n.4, pp.365-369. ISSN 0716-1018.  http://dx.doi.org/10.4067/s0716-10182017000400365.

Background:

Histoplasmosis is an endemic fungal infection in Peru and HIV coinfection leads to difficult diagnoses and high associated mortality.

Aim:

To describe clinical, epidemiological and clinical outcomes in patients with HIV infection with diagnosis of disseminated histoplasmosis (DH) at Guillermo Almenara Irigoyen National Hospital, Lima, Peru.

Methods:

Retrospective, descriptive study; information was obtained from the computer registry of patients with HIV infection diagnosed with DH, during the period 1996-2014. Clinical, epidemiological, treatment and outcome characteristics were described.

Results:

We found 27 patients, 25 (92.6%) were male, with a mean age of 36.7 years (± 9.4 years) and 22 (81.5%) had an epidemiological history contact. Sixteen patients (59.3%) had DH as an AIDS defining disease. The median CD4 count was 65 cells/mm3 (IQR 15-92). Only 7 (25.9%) received combination antiretroviral therapy at diagnosis. The most common clinical presentation was fever (66.7%), chronic diarrhea (40.7%) and lymphadenopathy (33.3%). The diagnosis was made mainly by histopathology. Six (22.2%) patiens died in the acute stage of the disease. Seven (25.9%) were initially treated empirically as tuberculosis.

Conclusion:

We describe the clinical characteristics of a group of patients who had DH as HIV coinfection and this is still a quasi endemic reality in patients suffering from this pathology.

Palabras clave : Histoplasmosis; AIDS; HIV infection; Peru (source MeSH NLM).

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