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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

TIRABOSCHI, Iris Nora et al. Epidemiology, species, antifungal resistance and outcome of candidemia in a university hospital in Buenos Aires, Argentina for 16 years. Rev. chil. infectol. [online]. 2017, vol.34, n.5, pp.431-440. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182017000500431.

Background:

The epidemiology of candidemia vary by region.

Aim:

To determine the epidemiology of candidemia in a hospital for 16 years.

Material and Methods:

Episodes of candidemia occurred in the Hospital de Clinicas of Buenos Aires were reviewed, from 01/01/98 to 31/12/13.

Results:

374 episodes of candidemia were identified. The incidence was 2.21/1,000 discharges and increased from 1.96 (1998-2005) to 2.25 (2006-2013) (p = 0.023). Candidemia was diagnosed: 5.4% in neonates, 1.7% in infants, 6.5% in children, 31.8% in adults and 52.7% in elderly adults over 64 years old. The episodes were caused by C. albicans (40.9%), C. parapsilosis (21.7%), C. tropicalis (15.5%), C. glabrata (13.9%), other species of Candida (5.1%) and more than one species of Candida (2.9%). The 5.3% of the isolates were resistant to fluconazole. 74% of patients were treated. Initial treatments were with fluconazole (70.3%), amphotericin B deoxycholate (25%), echinocandins or lipidic amphotericin (4,7%). The 81% of central venous catheters were taken off. Mortality rate was of 47.9%, but in the elderly adults was of 60.8%.

Conclusion:

The incidence of candidemia showed an increase over the years. It was higher in the elderly adults, being the group with worse outcomes.

Palabras clave : Candidemia; epidemiology; Candida spp; sensitivity; fluconazole; evolution.

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