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Revista chilena de infectología

Print version ISSN 0716-1018

Abstract

LIPARI, Flavio G. et al. Bloodstream infection in patients receiving hematopoietic stem cell transplant. Seven years of experience with adults and children. Rev. chil. infectol. [online]. 2017, vol.34, n.6, pp.535-538. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182017000600535.

Background:

Bloodstream infection is a common complication, which can be life-threatening for hematopoietic stem cells transplant recipients.

Objective:

To analyze the characteristics of bloodstream infections in hematopoietic stem cell transplant recipients.

Materials and Methods:

Observational, retrospective study. We reviewed the records of 451 patients (autologous and allogeneic transplants) from January 2009 to October 2015.

Results:

99 positive blood cultures in 73 patients with bloodstream infection (16%) were found. Mortality attributable to infectious causes was 17%. From the 99 bloodstream infection, 63% were caused by gram-negative bacilli (Escherichia coli 45%, Klebsiella spp 23%, Pseudomonas spp 11% Acinetobacter spp % and other bacilli 15%), 33% by gram-positive cocci, 3% by fungi and 1% by gram-positive bacilli. The gram-negative bacilli were ciprofloxacin resistant (81%), piperacillin/tazobactam resistant (48%), extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae (40%), cefepime resistant (39%) and there was no resistance noted to amikacin.

Discussion:

There is a higher frequency of gram-negative bacilli infection, with a high percentage of multiresistant microorganisms and high resistance to empirical antibiotic treatment.

Keywords : Bone marrow transplant; bloodstream infection; etiology; susceptibility; neutropenia.

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