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Revista chilena de infectología

Print version ISSN 0716-1018


VEGA, Juan Rojas De la; BENADOF, Dona; VEAS, Abigail  and  ACUNA, Mirta. Enterobacteriaceae susceptibility to piperacillin/tazobactam in a Chilean pediatric hospital. Rev. chil. infectol. [online]. 2017, vol.34, n.6, pp.563-569. ISSN 0716-1018.


Enterobacteriaceae are a group of gram-negative rods that can cause serious infections in humans. A susceptibility in Klebsiella pneumoniae of 79.4% to piperacillin/tazobactam (PIP/TAZO) is reported in pediatric hospitals in Chile. There is no published data published to date regarding PIP/TAZO susceptibility to other Enterobacteriaceae species in this population.


To measure the in vitro PIP/TAZO susceptibility in Enterobacteriaceae isolates from patients in a pediatric hospital in Chile.


Descriptive and prospective study of Enterobacteriaceae positive cultures from patients assisting to the “Hospital de niños Roberto del Río” (HRRIO) between January 2013 and August 2014. PIP/TAZO susceptibility was established by gradient diffusion method (E-test®) according to the 2014 CLSI standards.


163 cases were included. The average age was 4 years and 15 days. 70.6% were female. 79.7% of samples were urine cultures. PIP/TAZO susceptibility in Enterobacteriaceae was 95.1% (n = 155). The intermediate susceptibility was 1.8% (n = 3).


The isolates studied present high susceptibility to PIP/TAZO. This finding could be explained by the fact that this population has not been exposed to this antimicrobial therapy and also the low rates for ESBL in pediatric infections.

Keywords : Enterobacteriaceae; piperacillin/tazobactam; drug resistance bacterial; children; Latin America; Chile.

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