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Revista chilena de infectología

Print version ISSN 0716-1018

Abstract

VEGA, Juan Rojas De la; BENADOF, Dona; VEAS, Abigail  and  ACUNA, Mirta. Enterobacteriaceae susceptibility to piperacillin/tazobactam in a Chilean pediatric hospital. Rev. chil. infectol. [online]. 2017, vol.34, n.6, pp.563-569. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182017000600563.

Introduction:

Enterobacteriaceae are a group of gram-negative rods that can cause serious infections in humans. A susceptibility in Klebsiella pneumoniae of 79.4% to piperacillin/tazobactam (PIP/TAZO) is reported in pediatric hospitals in Chile. There is no published data published to date regarding PIP/TAZO susceptibility to other Enterobacteriaceae species in this population.

Aim:

To measure the in vitro PIP/TAZO susceptibility in Enterobacteriaceae isolates from patients in a pediatric hospital in Chile.

Methods:

Descriptive and prospective study of Enterobacteriaceae positive cultures from patients assisting to the “Hospital de niños Roberto del Río” (HRRIO) between January 2013 and August 2014. PIP/TAZO susceptibility was established by gradient diffusion method (E-test®) according to the 2014 CLSI standards.

Results:

163 cases were included. The average age was 4 years and 15 days. 70.6% were female. 79.7% of samples were urine cultures. PIP/TAZO susceptibility in Enterobacteriaceae was 95.1% (n = 155). The intermediate susceptibility was 1.8% (n = 3).

Discussion:

The isolates studied present high susceptibility to PIP/TAZO. This finding could be explained by the fact that this population has not been exposed to this antimicrobial therapy and also the low rates for ESBL in pediatric infections.

Keywords : Enterobacteriaceae; piperacillin/tazobactam; drug resistance bacterial; children; Latin America; Chile.

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