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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

SANCHEZ, M. Alexandra; PINO, Jessica; PACHECO, Robinson  y  GARCIA, José Fernando. Lethality analysis in patients with tuberculosis diagnosis in a high complexity hospital in Cali, Colombia. Rev. chil. infectol. [online]. 2018, vol.35, n.2, pp.133-139. ISSN 0716-1018.  http://dx.doi.org/10.4067/s0716-10182018000200133.

Background

In 2016 tuberculosis (TB) was considered the ninth leading cause of death worldwide and the leading cause of a single infectious agent, with approximately 1.6 million deaths worldwide and a lethality of 15%. Over 95% of cases and deaths are in developing countries like Colombia.

Aim:

To describe the sociodemographic and clinical characteristics of patients who died during TB treatment in a high complexity hospital in Cali, Colombia.

Methods:

We conducted an analytic retrospective cohort during 2007-2016 in Fundación Valle del Lili. We included patients with TB diagnosis, who died during TB treatment.

Results:

From 787 patients with TB, 69 died (8.8%). Fifty nine percent were male, the average of age was 51.9 years. There was diagnosis delay in 51% of the patients and 74% presented pulmonary TB. Sixty four percent 64 died in the first 30 days of the TB diagnosis and 61% of the deaths were attributable to TB. Twenty five percent of patients had TB/HIV coinfection. Elderly patients (> 65 years old) were associated with death in the first 30 days of TB diagnosis (p < 0,001).

Discussion:

The lethality found in this study was higher than expected (8.8%), the majority of patients had serious comorbidities. Elderly patients were associated with early death. The main pathophysiological mechanism of death was septic shock caused by severe tuberculous pneumonia.

Palabras clave : Mycobacterium tuberculosis; Mortality; HIV/AIDS.

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