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Revista chilena de infectología

versão impressa ISSN 0716-1018

Resumo

CORTES, Jorge; KRAL, Alejandro  e  WILSON, Gonzalo. Cryptococcosis in Hospital Carlos Van Buren, Valparaiso: a clinical serie. Rev. chil. infectol. [online]. 2018, vol.35, n.4, pp.420-423. ISSN 0716-1018.  http://dx.doi.org/10.4067/s0716-10182018000400420.

Background:

Cryptococcosis is a severe opportunistic mycotic infection, caused mainly by Cryptococcus neoformans. It can present as meningitis, pneumonia or cryptococcemia.

Aim:

To characterize patients with Cryptococcus infection between January 1°, 2013 and June 30, 2016, in Hospital Carlos van Buren, Valparaíso, Chile.

Methods:

We identified retrospectively those cultures with Cryptococcus sp. growth, and then obtained their clinical files which were analyzed by two independent reviewers.

Results:

We were able to obtain data from 13 of 15 patients who presented with Cryptococcus neoformans infection. Out of all, 11 (84.6%) were males, with a median age of 35 years old. 11 (84,6%) were HIV positive, 1 (7,7%) had chronic lymphocytic leukemia, and 1 (7,7%) refered alcohol abuse. Out of the 15 episodes, 9 (60%) had meningeal infection; 5 (33.3%) were cryptococcemia without meningeal involvement and 1 (6.6%) presented as a pulmonary infection. Eight patients were deceased at one year follow up.

Conclusions:

Cryptococcus sp. infection must be suspected in patients with cellular immunodeficiencies. Meningeal involvement is the most frequent form of clinical presentation. It still has a high mortality rate.

Palavras-chave : Cryptococcus neoformans; cryptococcocus; meningitis; AIDS.

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