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Revista chilena de infectología

versión impresa ISSN 0716-1018


SAMUDIO, Gloria Celeste; MONZON, Ruth; ORTIZ, Lidia María  y  GODOY, Gladys Maribel. Late onset neonatal sepsis in an intensive care neonatal unit: etiological agents and most frequent location. Rev. chil. infectol. [online]. 2018, vol.35, n.5, pp.547-552. ISSN 0716-1018.


Nosocomial neonatal sepsis (NNS) is a frequent entity in intensive care units, causing great morbidity and mortality. The most frequent site is blood, followed by lungs and urine.


To know the etiology and most frequent localization of infection in the NNS.

Population, Material and Methods:

Cross sectional study, from January to December 2015, performed in a teaching hospital. All newborns infants were included.


70 patients were included, 88 episodes of NNS were analyzed. The most frequent localization was bacteremia in 40% of cases, followed by urinary tract infection and VAP in 25% respectively. The bacteria most frequently isolated were staphylococci of different types, followed by multiresistant Acinetobacter. The CNS involvement was 32%. Mortality was 34%, rising up to 50% with a second episode of NNS. The empirical therapy of choice was vancomycin and carbapenem, adjusting to antibiogram.


The most frequent infection was bacteremia, mainly by staphylococci resistant to methicillin. CNS involvement was elevated, as well as mortality.

Palabras clave : Late onset neonatal sepsis; nosocomial neonatal sepsis; etiology; infection sites.

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