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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

DELAMA, Ignacio et al. Evaluation of the lateral flow Aspergillus assay for the diagnosis of invasive aspergillosis, experience in a university hospital. Rev. chil. infectol. [online]. 2018, vol.35, n.5, pp.574-579. ISSN 0716-1018.  http://dx.doi.org/10.4067/s0716-10182018000500574.

Background:

The incidence of invasive aspergillosis is increasing. Its diagnosis is based on clinical and microbiological criteria which include the determination of serological markers such as galactomannan. Recently, the Aspergillus lateral flow device, an inmunocromatograph assay has been described for its diagnosis.

Aim:

To evaluate the performance of the lateral flow device for the diagnosis of invasive aspergillosis (IA) in adult patients.

Material and Method:

In this cross-sectional study, frozen samples that had been previously evaluated for galactomannan from patients classified with proven/probable/possible or no AI according to the EORTC/MSG criteria were selected.

Results:

A total of 142 samples from 98 patients were processed, corresponding to proven AI 5.6%, probable IA 41.5%, possible IA 12.7% and no-IA 40.1%. The sensitivity and specificity of the Aspergillus lateral flow was 70.9% and 53.5% for serum samples and 83.3% and 38.5% for BAL samples. The concordance between the galactomannan and Aspergillus lateral flow was 62.4% (54.1 – 69.9) with a Kappa index of 0.202 (0.03682 – 0.3669).

Conclusions:

We observed a good sensitivity but low specificity, a positive result need a confirmatory test.

Palabras clave : Aspergillus; diagnosis; lateral flow device.

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