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Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

GUTIERREZ, Catalina et al. Clinical utility of HIV viral load assessment in cerebral spinal fluid, a case report. Rev. chil. infectol. [online]. 2018, vol.35, n.5, pp.601-605. ISSN 0716-1018.  http://dx.doi.org/10.4067/s0716-10182018000500601.

Detection of virus in cerebrospinal fluid (CSF) in HIV-infected patients with HIV viral load (VL) undetectable in plasma has been termed viral escape. These leaks may be asymptomatic from a neurological point of view, similar to plasma blips, or associated with neurological disease, with discordant VL between plasma and CSF, and may be evidence of a compartmentalization of the virus and the possibility of identifying quasispecies with mutations that confer resistance to ART. We present the case of a man with AIDS and disseminated tuberculosis who presented neurological symptomatology evidenced by headache and convulsive syndrome, who presented a discordance between plasma and CSF HIV VL; the genotypic test of the virus, obtained by lumbar puncture, identified new mutations that determined a change in ART with subsequent satisfactory evolution.

Palabras clave : HIV; HIV viral load; cerebrospinal fluid; viral escape.

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