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Biological Research

Print version ISSN 0716-9760


LEON, OSCAR  and  ROTH, MONICA. Zinc fingers: DNA binding and protein-protein interactions. Biol. Res. [online]. 2000, vol.33, n.1, pp.21-30. ISSN 0716-9760.

The zinc finger domain is a very ubiquitous structural element whose hallmark is the coordination of a zinc atom by several amino acid residues (cysteines and histidines, and occasionally aspartate and glutamate). These structural elements are associated with protein-nucleic acid recognition as well as protein-protein interactions. The purpose of this review is to examine recent data on the DNA and protein binding properties of a few zinc fingers whose three dimensional structure is known

Keywords : Zinc fingers; DNA binding; protein-protein interactions.

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