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Biological Research

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COSTA, MARCO ANTONIO; SILVA, NELMARA CRISTINA GONÇALVES  and  CASTRO-PRADO, MARIALBA AVEZUM ALVES. Genetic and cytological characterization of a developmental mutant of Aspergillus nidulans induced by 5-azacytidine. Biol. Res. [online]. 2001, vol.34, n.2, pp.91-98. ISSN 0716-9760.

An analysis of a new medusa mutant of Aspergillus nidulans obtained by 5-azacytidine-treatment and named B116 is provided. The B116 mutant was phenotypically characterized by the production of conidiophores with reduced pigmentation and vesicles bearing multiple tiers of sterigmata. A single nuclear gene located on chromosome I is responsible for phenotypical changes in the mutant. The 5-azacytidine-altered locus, designated medA102, is recessive in heterozygous diploid and the medusa mutant is a Dp(II,I) duplication bearer that renders the strain mitotically unstable.

Keywords : conidiation; developmental program; medusa.

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