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Biological Research

Print version ISSN 0716-9760

Abstract

ABD-ALLAH, NADIA M; HASSAN, FAYEZA H; ESMAT, AMR Y  and  HAMMAD, SOMAYA A. Age Dependence of the Levels of Plasma Norepinephrine, Aldosterone, Renin Activity and Urinary Vanillylmandelic Acid in Normal and Essential Hypertensives. Biol. Res. [online]. 2004, vol.37, n.1, pp.95-106. ISSN 0716-9760.  http://dx.doi.org/10.4067/S0716-97602004000100010.

In the present study the upper reference limits (URLs) for resting plasma norepinephrine, epinephrine, serum aldosterone, plasma renin activity, aldosterone/ renin activity ratio, as well as urinary vanillylmandelic acid in healthy Egyptian normotensive subjects over a range of ages (5-60 yr) were established. There was a significant age effect on plasma norepinephrine, UVMA, serum aldosterone and PRA, whereas a single URL for plasma epinephrine level is satisfactory. In uncomplicated untreated essential hypertensive subjects (5-60 yr), the average prevalence of elevation in the plasma norepinephrine, epinephrine and urinary vanillylmandelic acid above their corresponding URLs was 85.10,62.15 and 83.20 %, respectively. This suggests that elevation in plasma catecholamine concentrations is more likely a common consequence than playing a possible role in the pathogenesis of hypertension, supported by insignificant correlation coefficients between the plasma catecholamine levels and resting systolic and diastolic blood pressure values (SBP&DBP) in all hypertensive age groups. Primary hyperaldosteronism was not detected among the normokalemic essential hypertensives at any age using aldosterone /plasma renin activity ratio as a primary screening method. In the present study, 7 statistically significant positive coefficient correlations are reported for SBP or DBP values with UVMA levels in hypertensive children and adolescents, serum aldosterone in old hypertensives, and PRA in adult hypertensives.

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