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Biological Research

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SANTILLAN, G; KATZ, S; BUITRAGO, C  and  BOLAND, R. 1a,25(OH)2D3 induces capacitative calcium entry involving a trpc3 protein in skeletal muscle and osteoblastic cells. Biol. Res. [online]. 2004, vol.37, n.4, pp.647-651. ISSN 0716-9760.

This work describes the involvement of TRPC proteins in capacitative calcium entry (CCE) induced by 1a,25-dihydroxy-vitamin-D3 [1a,25(OH)2D3] in chick skeletal muscle and in rat osteoblast-like cells (ROS 17/2.8) and the role of the vitamin D receptor (VDR) in this non-genomic rapid response mediated by the hormone. We propose that an endogenous TRPC3 protein mediates 1a,25(OH)2D3 modulation of CCE in these cells, which seems to implicate VDR-TRPC3 association and the participation of an INAD-like scaffold protein.

Keywords : CCE; TRPC; muscle cells; osteoblasts; 1a,25(OH)2D3; VDR; INAD.

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