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Biological Research

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CAMPANELLA, MICHELANGELO; PINTON, PAOLO  and  RIZZUTO, ROSARIO. Mitochondrial Ca2+ homeostasis in health and disease . Biol. Res. [online]. 2004, vol.37, n.4, pp.653-660. ISSN 0716-9760.

Although it has long been known that mitochondria possess a complex molecular repertoire for accumulating and releasing Ca2+, only in recent years has a large body of data demonstrated that these organelles promptly respond to Ca2+-mediated cell stimulations. In this contribution, we will review the principles of mitochondrial Ca2+ homeostasis and its signaling role in different physiological and pathological conditions.

Keywords : Mitochondria; Calcium; Apoptosis; Bcl-2; viral proteins.

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