SciELO - Scientific Electronic Library Online

 
vol.38 issue2-3 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Biological Research

Print version ISSN 0716-9760

Abstract

LOPEZ-LASTRA, MARCELO; RIVAS, ANDREA  and  BARRIA, MARÍA INÉS. Protein synthesis in eukaryotes: The growing biological relevance of cap-independent translation initiation. Biol. Res. [online]. 2005, vol.38, n.2-3, pp.121-146. ISSN 0716-9760.  http://dx.doi.org/10.4067/S0716-97602005000200003.

Ribosome recruitment to eukaryotic mRNAs is generally thought to occur by a scanning mechanism, whereby the 40S ribosomal subunit binds in the vicinity of the 5'cap structure of the mRNA and scans until an AUG codon is encountered in an appropriate sequence context. Study of the picornaviruses allowed the characterization of an alternative mechanism of translation initiation. Picornaviruses can initiate translation via an internal ribosome entry segment (IRES), an RNA structure that directly recruits the 40S ribosomal subunits in a cap and 5' end independent fashion. Since its discovery, the notion of IRESs has extended to a number of different virus families and cellular RNAs. This review summarizes features of both cap-dependent and IRES-dependent mechanisms of translation initiation and discusses the role of cis-acting elements, which include the 5'cap, the 5'-untranslated region (UTR) and the poly(A) tail as well as the possible roles of IRESs as part of a cellular stress response mechanism and in the virus replication cycle

Keywords : protein synthesis; translation initiation; internal ribosome entry segment.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License