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Biological Research

Print version ISSN 0716-9760

Abstract

GALARCE, GLORIA D et al. Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion. Biol. Res. [online]. 2008, vol.41, n.1, pp.43-50. ISSN 0716-9760.  http://dx.doi.org/10.4067/S0716-97602008000100006.

This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents

Keywords : anti-inflammatory agents; benzimidazoquinazoline derivatives; TNF-á inhibitors.

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