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Biological Research

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VIDELA, Luis A. Cytoprotective and suicidal signaling in oxidative stress. Biol. Res. [online]. 2010, vol.43, n.3, pp.363-369. ISSN 0716-9760.

Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (i) the development of an acute and mild pro-oxidant state by thyroid hormone administration eliciting the redox upregulation of the expression of proteins affording cell protection as a preconditioning strategy against ischemia-reperfusion liver injury; and (ii) the role of prolonged and severe oxidative stress and insulin resistance as determinant factors in the pathogenesis of non-alcoholic fatty liver disease associated with obesity.

Keywords : oxidative stress; thyroid hormone; liver preconditioning; obesity; insulin resistance; non-alcoholic fatty liver disease.

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