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vol.43 issue4Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodentsDivergent effects of Nitric oxide on airway epithelial cell activation author indexsubject indexarticles search
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Biological Research

Print version ISSN 0716-9760

Abstract

MORAES DE CARVALHO, Katharinne I et al. Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents. Biol. Res. [online]. 2010, vol.43, n.4, pp.459-465. ISSN 0716-9760.  http://dx.doi.org/10.4067/S0716-97602010000400011.

This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75 %), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.

Keywords : antioxidant; antiulcer activity; Encholirium spectabile; Bromeliaceae.

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