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Biological Research

Print version ISSN 0716-9760

Abstract

GARCIA-LABASTIDA, Laura et al. CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast. Biol. Res. [online]. 2014, vol.47, pp.1-5. ISSN 0716-9760.  http://dx.doi.org/10.1186/0717-6287-47-43.

BACKGROUND: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. RESULTS: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. CONCLUSIONS: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.

Keywords : Breast mucinous carcinoma; Inmunohistochemical; Intestinal differentiation.

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