SciELO - Scientific Electronic Library Online

vol.50Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cellsMolecular and functional characterization of ferredoxin NADP(H) oxidoreductase from Gracilaria chilensis and its complex with ferredoxin author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Biological Research

Print version ISSN 0716-9760


XING, Haijie; CHEN, Xiangdong  and  HAN, Yaofeng. Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma. Biol. Res. [online]. 2017, vol.50, 37. ISSN 0716-9760.


Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC.


We have found that there was 63 patients with REGIA positive expression of 155 patients in this study (40.65%). The positive expression rate of REGIA was 30.50, 44.44 and 47.83% in stage T2, T3 and T4 patients, respectively. The REGIA expression was significantly difference in T2 and T4 stage tumors or T2 and T3–T4 stage. The positive expression rate of REGIA was found to be higher in patients with cervical lymph node persistence than those with cervical lymph node complete regression. Patients with negative REGIA expression had a better overall survival and free survival than those with REGIA positive expression. In addition, according to the univariate and multivariate analysis, the REGIA expression was an independent adverse prognostic factor for NPC patients.


REGIA expression was a useful biomarker in NPC patients for assessing T stage and survival.

Keywords : Nasopharyngeal carcinoma; Regenerating gene IA; Invasion; Survival.

        · text in English     · English ( pdf )