SciELO - Scientific Electronic Library Online

 
vol.51Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cellsProtective roles of autophagy in retinal pigment epithelium under high glucose condition via regulating PINK1/Parkin pathway and BNIP3L author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Biological Research

Print version ISSN 0716-9760

Abstract

LIN, Ruhui et al. Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice. Biol. Res. [online]. 2018, vol.51, 21.  Epub July 24, 2018. ISSN 0716-9760.  http://dx.doi.org/10.1186/s40659-018-0166-7.

Objective

To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease.

Methods

N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot.

Results

EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice.

Conclusion

These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.

Keywords : Magnetic resonance spectroscopy (MRS; Electroacupuncture; Learning and memory; N-Acetylaspartate (NAA; Glutamate (Glu).

        · text in English     · English ( pdf )