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vol.18 issue2COMPARATIVE MORPHOLOGY OF THE OVARIES OF THREE SPECIES OF DASYPODIDAE (MAMMALIA, XENARTHRA)FINE STRUCTURE OF THE BOUNDARY TISSUE OF THE EPIDIDYMAL DUCT OF THE DOG (Canis familiaris, L.) author indexsubject indexarticles search
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Revista chilena de anatomía

Print version ISSN 0716-9868

Abstract

ROCHA MENDES, Eliane Terezinha et al. Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats. Rev. chil. anat. [online]. 2000, vol.18, n.2, pp.259-263. ISSN 0716-9868.  http://dx.doi.org/10.4067/S0716-98682000000200007.

As a less potent opioid analgesic and CNS depressant than morphine, propoxyphene abuse constitutes a potential risk among pregnant women. Since literature data indicate the possibility of serious side effects on liver compartment, in this work we examined the effects the chronic administration of this drug on both pregnant rats and their concepts. Female rats were treated during the entire pregnancy (from day 0 up to day 20) with 5, 15 or 45 mg/kg of propoxyphene napsylate once daily, by gavage. Controls received the drug vehicle. At term, samples from both maternal and foetal kidneys and livers were taken and prepared for optical and electron microscopy examination. Upon optical microscopy or electron microscopy examination, no morphological alterations were seen on either maternal or foetal livers of propoxyphene-treated pregnant rats. However, maternal and foetal kidneys showed signs of toxicity mainly in the group of rats treated with the highest dose of the drug, especially at the proximal convoluted tubules. Our results suggest that, in the rat, the physiological modifications inherent to pregnancy shifted the main focus of toxicity of propoxyphene from the liver to the kidney. The mechanisms involved in such phenomenon are at present unresolved

Keywords : Propoxyphene; Toxycology; Kidney; Liver; Rat; Pregnancy.

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