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Electronic Journal of Biotechnology

On-line version ISSN 0717-3458

Abstract

EBRAHIMI, Mahdi et al. Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats. Electron. J. Biotechnol. [online]. 2015, vol.18, n.3, pp.210-214. ISSN 0717-3458.  http://dx.doi.org/10.1016/j.ejbt.2015.03.009.

Background There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-α) and stearoyl-CoA-desaturase (SCD) in the liver. Results An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P < 0.05) up-regulation of PPAR-α gene expression and downregulation of SCD gene in the liver of goats fed the high α-linolenic acid diet. Conclusions In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the α-linolenic acid supplementation in the goat diet. It is suggested that PPAR-α is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression.

Keywords : Gene expression; Goat; Liver; Omega-3 fatty acid; PPAR.

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