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Revista chilena de enfermedades respiratorias

versão On-line ISSN 0717-7348


FERNANDEZ V, PATRICIA  e  JIMENEZ P, PATRICIO. Bronchiectasis: Is it no longer considered an orphan disease?. Rev. chil. enferm. respir. [online]. 2016, vol.32, n.3, pp.169-177. ISSN 0717-7348.

Bronchiectasis, so far considered an orphan disease, currently is diagnosed with a higher frequency due to several reasons such as renewed awareness of the disease, better diagnosis including imagenology, the development of patients registries, as well as a higher number of clinical research studies. The pathological basis of bronchiectasis is widely variable. Also the clinical expression is variable, from absence of symptoms in some patients up to chronic sputum production in others. Furthermore, a group of patients often develop recurrent exacerbations. Despite the etiologies of bronchiectasis are diverse, the main etiology is previous pulmonary infection. On the other hand, bronchiectasis could also be the expression of diverse systemic diseases. Even around one quarter of patients the etiology would not be established. The development of large registries of patients has allowed the building of classifications systems with accurate prognostic criteria. Chronic infection is the most relevant issue in bronchiectasis. Infection with P. aeruginosa has been associated with poor prognosis and their eradication must be attempted always. Effective secretions drainage techniques, oral and nebulized antibiotics, as well as mucolytic therapy are the mainstay of treatment in bronchiectasis.

Palavras-chave : Bronchiectasis; antibacterial agents; Pseudomonas aeruginosa; respiratory tract infections.

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