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Revista chilena de enfermedades respiratorias

versión On-line ISSN 0717-7348


PENA M., Carlos  y  FARGA C., Victorino. Advances in the treatment of multi-drug resistant tuberculosis. Rev. chil. enferm. respir. [online]. 2017, vol.33, n.2, pp.137-141. ISSN 0717-7348.

Therapy of multi-drug resistant tuberculosis (MDR TB) is based on trials with drugs with highly variable patterns of resistance and non-standardized follow-ups that make it difficult to provide recommendations with strong levels of evidence. Also, the vast majority of MDR-TB patients fail to receive therapy and those who receive it, only achieve around 50% of good results. Fortunately new drugs have emerged (bedaquiline, delamanid, pretomanid) that are being useful for these patients with better designed trials and monitoring, in which the efficacy, toxicity and degree of relapses can be evaluated more accurately. Some drugs already known (fluorquinolones, linezolid and clofazimine) are also being introduced in new schemes of therapy.

Palabras clave : Tuberculosis, multidrug-resistant; bedaquiline; oxazoles.

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