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Revista chilena de enfermedades respiratorias

On-line version ISSN 0717-7348

Abstract

SEPULVEDA L., Claudia et al. Lung transplantation in pulmonary fibrosis. An experience from National Institute of Thorax, Chile. Rev. chil. enferm. respir. [online]. 2019, vol.35, n.1, pp.15-21. ISSN 0717-7348.  http://dx.doi.org/10.4067/S0717-73482019000100015.

Pulmonary fibrosis is a progressive disease with a bad prognosis. This situation makes rise lung transplant as a therapeutic option among carefully selected patients.

Objective:

Evaluate the results and survival rates of patients with pulmonary fibrosis that were transplanted through an 8 years period of follow-up, from the beginning of our transplant program.

Methods:

Descriptive study of the transplanted patients diagnosed with pulmonary fibrosis from august 2010 to july 2018.

Results:

Out of 76 transplants, 68.4% were due to pulmonary fibrosis, among these, the main diagnosis was idiopathic pulmonary fibrosis (75%). The average lung allocation score (LAS) was 53 and 32% of them had urgency criteria. Patients ’ age averaged 55 years-old and 98% of them underwent a single lung transplant. Early medical complications were seen in 26 patients with infectious episodes and 6 with acute rejection. The main late complication was chronic allograft dysfunction. The main surgical complication was bronchial stenosis (7.6%). In comparison to its base line reference values FVC means pre transplant and 1 and 3 years post-transplant were 49%, 70% and 71% respectively. A 40% of patients died during follow up period. Infections were the main cause of mortality during the first year. Survival rates at 1st 3rd and 5th year were 86,2%; 65.2% and 59.8% respectively.

Conclusions:

Single lung transplant is a therapeutic option for patients with interstitial lung disease with a 59% survival rate in 5 years, 1/3 fulfilled urgency criteria at the transplant time. The infections were the main early complication and chronic graft dysfunction was the main late complication.

Keywords : Lung transplantation; idiopathic pulmonary fibrosis; survival rate; follow-up studies.

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