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Revista chilena de enfermedades respiratorias

On-line version ISSN 0717-7348

Abstract

SANDOVAL D., Bárbara; REYES R., Tatiana  and  OYARZUN G., Manuel. Mechanisms of noxious effects of wildfire air pollution over human health. Rev. chil. enferm. respir. [online]. 2019, vol.35, n.1, pp.49-57. ISSN 0717-7348.  http://dx.doi.org/10.4067/S0717-73482019000100049.

Wildfires represent a growing global public health issue, especially to the most vulnerable segment of the population (children, old people, pregnant women, patients with cardiovascular or respiratory diseases) exposed to smoke and other air borne contaminants generated from these events. In contrast to great cities ’ usual atmospheric pollution, that derives from forest fires differ in composition and its occurrence is sporadic and usually unpredictable. Exposure to atmospheric pollutants derived from forest fires has been associated to increased respiratory and cardiovascular morbidity, mediated by an inflammatory systemic response, oxidative stress and endothelial dysfunction. In people exposed to forest fire smoke an increased production of pro-inflammatory cytokines, endothelial activation and autonomic nervous system dysfunction has been observed, that leads to tissue injury, increased prothrombotic response, increased blood pressure and changes in heart rhythm. This review analyzes the mechanisms that have been involved in generating harmful health effects in humans exposed to inhaled particulate matter and gases steaming from wildfires.

Keywords : Wildfires; particulate matter; cytokines; oxidative stress; lung injury; cardiovascular diseases.

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