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Revista chilena de enfermedades respiratorias

versão On-line ISSN 0717-7348

Resumo

FERNANDEZ F, CRISTINA  e  MENESES C, MANUEL. Histopathological criteria for the diagnosis of idiopathic pulmonary fibrosis. Rev. chil. enferm. respir. [online]. 2019, vol.35, n.4, pp.275-277. ISSN 0717-7348.  http://dx.doi.org/10.4067/S0717-73482019000400275.

In the latest update of the ATS/ERS/JRS/ALAT Clinical Practice Guidelines for idiopathic pulmonary fibrosis (IPF), a new way of classifying histopathological patterns in 4 types is proposed: definitive usual interstitial pneumonia (UIP), probable UIP, indeterminate and alternative to UIP. A heterogeneous fibrotic remodeling of the normal architecture of the pulmonary parenchyma, with destructive scarring in the form of “honeycomb”, presence of fibroblastic foci and predominantly subpleural and paraseptal distribution, with scarce chronic interstitial inflammatory infiltrate, associated with the absence of elements suggestive of secondary causes such as bronchiolocentric distribution, predominance of inflammatory interstitial infiltrates or poorly formed granulomas, allows an accurate diagnosis of IPF in an appropriate clinical-radiological scenario.

Palavras-chave : Idiopathic pulmonary fibrosis; Fibroblasts; Architecture.

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