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vol.30 número3INVESTIGACIÓN ALIMENTARIA: CONSIDERACIONES PRACTICAS PARA MEJORAR LA CONFIABILIDAD DE LOS DATOSNIVELES PLASMATICOS DE VITAMINA D E INGESTA DE CALCIO EN NIÑOS CELIACOS: FACTORES DE RIESGO PARA SU SALUD FUTURA índice de autoresíndice de materiabúsqueda de artículos
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Revista chilena de nutrición

versión On-line ISSN 0717-7518

Resumen

OBREGON L, Maria-Clara et al. REGULAR OF LACTOBACILLUS JHONSONII LA1 INTERFERES WITH HELICOBACTER PYLORI COLONIZATION. Rev. chil. nutr. [online]. 2003, vol.30, n.3, pp.243-249. ISSN 0717-7518.  http://dx.doi.org/10.4067/S0717-75182003000300004.

colonized by Helicobacter pylori (Hp). The aim of this study was to evaluate whether regular intake of a commercial product containing Lactobacillus johnsonii La1 (La1) interferes with gastric colonization by Hp and whether this effect may be greater when the frequency of the product intake is higher. A first randomized double-blind clinical trial was carried out in children 6 to 17 years of age attending school in a low socioeconomic area of Santiago. Children found to be Hp-positive by the 13C-urea breath test (13C-UBT) were distributed into 3 groups to receive daily 160 ml, during 4 weeks, of one of the three following treatments: 1) a product with live La1, 2) the same product after thermization, i.e. including killed La1 or 3) the same product without La1 (control). A second 13C-UBT was carried out at the end of the study. In the second study, 11 asymptomatic adult volunteers evaluated as Hp-positive by 13C-UBT were recruited. They had to ingest 80 ml of the product with live La1 every two hours every day between 8:00h and 22:00h (i.e. a total volume of 640 ml). A second and third 13C-UBT were carried out after 1 and 2 weeks of La1 ingestion. All breath samples were analyzed by mass spectrometry and results were expressed as 13C excess over basal levels: (DOB, ‰‰n the first study, a significant decrease, 11.9% (p<0.05), was observed in the children after 4 weeks of La1 consumption in comparison with the basal values before treatment, while no differences were observed in the other 2 groups. In the study with volunteers, DOB values decreased significantly during the study (Anova F=4.2, p<0.04), resulting in a decrease of 41% in comparison with the basal DOB values. In both studies a correlation was observed between basal DOB values and the magnitude of the decrease of DOB induced by La1. These results indicate that regular intake of L. johnsonii La1 interferes with Hp in subjects colonized with this pathogen, this effect is greater when La1 intake is more frequent, and it is positively related to the basal levels of colonization with Hp. Consumption of La1 modulates gastric colonization by Hp in populations at risk for this infection and constitutes an interesting alternative for its management

Palabras clave : probiotics; children; healthy volunteers.

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