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Revista chilena de nutrición

On-line version ISSN 0717-7518

Abstract

ABBRUZZESE J, Daniela V; GONZALEZ B, Claudia B; PEREZ M.-COLL, Cristina S  and  FONOVICH A. DE SCHROEDER, Teresa M. A NEW APPROACH TO THE TOXICOLOGY OF FOOD COLORANTS: HEPATIC CONJUGATION OF INDIGOTIN WITH PHOSPHOLIPIDS. Rev. chil. nutr. [online]. 2005, vol.32, n.1, pp.42-47. ISSN 0717-7518.  http://dx.doi.org/10.4067/S0717-75182005000100005.

We have demonstrated that the solubility of the food colorant indigotin was modified in mammalian liver, where it becomes totally insoluble in aqueous solvents and highly soluble in organic ones. This work presents the results from the studies on the chromatographic mobility of indigotin present in the lipidic extract obtained from rat liver 20 minutes after its intravenously administration. The presence of functional groups corresponding to its probable conjugation with phospholipids was also studied in the extract prepared from the colorant spot separated by thin layer chromatography of phospholipids. 0,144 +/- 0,087 _g of phospholipidic phosphorus were detected and fatty acid presence was demosntrated in this fraction, obtained from liver extract prepared with 2 grams of tissue. These results confirm the increment of the colorant solubility in organic solvents once it is incorporated in the liver and they suggest that it suffers a probably conjugation with phospholipids in this organ

Keywords : food colorant; indigotin; liver metabolism; lipids.

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