Resumen

CORNEJO U., Ricardo. LAS CÉLULAS MAMARIAS EN PROCESO DE DIFERENCIACIÓN DISMINUYEN SU VOLUMEN CITOPLASMÁTICO Y NUCLEAR. Rev. chil. obstet. ginecol. [online]. 2005, vol.70, n.3, pp.156-159. ISSN 0048-766X.  http://dx.doi.org/10.4067/S0717-75262005000300005.

The changes suffered during the biological process on cell differentiation posses complex and fundamental changes in cell ultrastructure, biochemistry and physiology that can clearly be observed using morphometric techniques, wich, once translated on quantitative information, allow to evince the transformations sustained by this mechanism. Cultured normal rat epithelial breast cells, stimulated to proliferate by epidermic growth factor, give origen to HC11 GM cell group. These normal-proliferative cells are induced to differentiate by lactogenic hormones, like dexamethasone, prolactine and insuline, generating a differenciated cellular type: HC11 IM. Discriminating morphometric data of these cell types along of the differentiation process was obtained by electronic microscopy studies showing also variation on cell size though demostrating new markers on the modification pattern that characterizes this process

Palabras clave : Cellular differentiation; morphometry; mammary glands.

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