Resumo

LOPEZ SM, Carlos et al. TUMOR DE CÉLULAS DE LA GRANULOSA OVÁRICO CON METÁSTASIS PULMONARES 26 AÑOS DESPUÉS. Rev. chil. obstet. ginecol. [online]. 2009, vol.74, n.5, pp.307-310. ISSN 0048-766X.  http://dx.doi.org/10.4067/S0717-75262009000500008.

Background: Granulosa cell tumor of the ovary (GCT) of the ovary is a sex cord related tumor. It is a low frequency neoplasm with low clinical progression but it may show late metastases. Objective: To present a 70 year old female with a GCT of the ovary with multiple pulmonary metastases after 26 years from the initial diagnosis of the primary tumor. Clinic case: The patient had an ovarian GCT diagnosed by histology in 1976 and underwent hysterectomy, bilateral salpingoophorectomy and chemotherapy. The clinical course was satisfactory until 2002 when she presented with respiratory symptoms and images showing multiple bilateral pulmonary nodules that were histologically confirmed to be GCT metastases. The patient underwent chemotherapy with platinum and ethoposide. Actually the patient is alive with metastatic disease. Conclusion: To the best of our knowledge, this is the third case in medical literature of a GCT of the ovary with late pulmonary metastases 26 years after the initial diagnosis. This case illustrates the protracted clinical course of the neoplasm and the importance of the long term follow up including levels of estradiol and inhibin.

Palavras-chave : Granulosa cell tumor; lung metastasis; ovary.

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